Brisket 1. Slightly dampen Brisket and rub thoroughly on all sides with generous amount of seasoning. 2. Refrigerate Brisket overnight for full flavor development and tenderization. 3. Bake covered in oven for 6 hours at 225 degrees or barbecue over low fire 8-12 hours until tender. Note: This seasoning can be used on any kind of meat, poultry or fish.